Nasal decongestants
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Administered as drops or a spray – fast acting, low systemic absorption
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Sympathomimetics, therefore, act on alpha receptors of smooth muscle and cause vasoconstriction of blood vessels. Reduce oedema of nasal mucosa, more efficient airflow.
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The main problem is rebound congestion due to secondary vasodilation with an increase in nasal congestion (Rhinitis Medicamentosa), so restricted to 7 days use
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Can also damage cilia and affect clearance of mucus
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Some systemic absorption possible – caution when using in patients with heart disease/hypertension/hyperthyroidism/narrow-angle glaucoma

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