Nasal decongestants 

• Administered as drops or a spray – fast acting, low systemic absorption

• Sympathomimetics, therefore, act on alpha receptors of smooth muscle and cause vasoconstriction of blood vessels. Reduce oedema of nasal mucosa, more efficient airflow.

• The main problem is rebound congestion due to secondary vasodilation with an increase in nasal congestion (Rhinitis Medicamentosa), so restricted to 7 days use

• Can also damage cilia and affect clearance of mucus

• Some systemic absorption possible – caution when using in patients with heart disease/hypertension/hyperthyroidism/narrow-angle glaucoma