Head & Neck Cancer - Larynx, Pharynx and Oral
This page introduces the common head and neck cancers that we see in the UK. It starts with some anatomy and a discussion of risk factors. Lower down you will find more information on laryngeal (supraglottic, glottic and subglottic), pharyngeal (nasopharyngeal, oropharyngeal and hypopharyngeal) and oral cancers.
• 21st most common cancer worldwide
• Incidence approximately 1 : 57,000
• 4:1 ratio ♂ : ♀
(These two factors have a synergistic effect in head & neck cancers when consumed together)
• HPV types 16, 18 – 25% all laryngeal cancers
• Family history
• Socioeconomic status
–HIV/ AIDs x 3
–Immunosuppresed e.g post-transplant x2
• Chemical exposure
–(Coal, formaldehyde, nickel, diesel fumes etc)
• Change in voice “Hoarse” > 3 weeks (80 – 90%)
• Dysphagia/ odynophagia
• FB sensation, food sticking
• Unexplained weight loss
• Shortness of breath, Stridor
• Neck lump
• Referred Otalgia (rare)
If you visit our red flags section you will see these symptoms are all classified as red flags in an ENT consultation.
• The larynx split into three:
– Supraglottis (40% of all laryngeal cancers)
(superior to apex of ventricle, laryngeal surface of the epiglottis, aryepiglottic folds, arytenoids, vestibubular folds, venticle)
Supraglottic tumours have a large area to grow in before they give symptoms and the area is well supplied with lymphatics. Therefore, more advanced disease with metastasis can develop here before presentation to a doctor.
– Glottic (50% of laryngeal cancers)
(Vocal cords, anterior and posterior commisure. Apex of ventricle to 1cm below it).
These present the earliest because they cause symptoms quickly. Hoarseness that is persistent should be evaluated to exclude carcinoma. Because of their early presentation and the relative lack of lymphatic drainage in the glottis, metastasis is relatively uncommon.
– Subglottic (10% of laryngeal cancers)
(Inferior border of glottis to lower border of cricoid cartilage)
The subglottis also has good lymphatic drainage but the area is very small so it produces symptoms fairly early.
Laryngeal cancers are of diverse histology but by far the commonest is squamous cell carcinoma, making 85% of all laryngeal malignancy. This section will concentrate on this disease due to its prevalence.
Squamous carcinoma is four times more common in men than women and peak incidence is between 55 and 65 years.
Risk factors for the disease are:
Radiation (for thyroid disease)
Hoarseness and airway compromise are symptoms common to all laryngeal tumours eventually but other symptoms and signs occur as the tumour extends:
Pain on swallowing
Remember that the risk factors for laryngeal cancer are the same as for lung cancer and it is not infrequent that the patient will have a laryngeal tumour and a lung primary.
• History & examination
The old saying goes 70% of diagnosis are made from the history alone.
• Flexible nasendoscopy
Direct visualisation of the larynx allows views of potential lesions to be made.
• CT/ MRI aerodigestive tract
- as part of staging and quantifying the size of any lesion
• Panendoscopy + biopsies
Allows the collection of specimens for histology.
• US neck +/- biopsies
Assess lymph node spread
The factors to consider in deciding on a treatment plan are as follows:
Performance status of the patient
Patient preference is important
Patient’s distance from the treatment facility
Availability of good quality imaging, pathology and surgeon
All of these must be weighed up before a decision can be arrived at. The options for treatment depend on the site of the tumour, the extent of the tumour and whether there are metastases or lung primaries or not. A combination of surgery and radiotherapy are usually opted for.
The pharynx has three sub-sites: the nasopharynx, the oropharynx, and the laryngopharynx. Tumours may occur in any of these and the symptoms that they produce will vary accordingly.
The base of the tongue and the tonsils are the commonest place for oropharyngeal cancer. Histologically squamous cell carcinoma is by far the most common with HPV being implicated in many. Lymphomas are the second most common tumour of the tonsil.
Ulceration or asymmetry of the tonsil should raise the suspicion of malignancy especially if there are other symptoms and signs. Pain, referred otalgia, bleeding, and neck nodes may all be present and trismus may arise through extension into the underlying pterygoid muscles.
Tongue base tumours may present late to the surgeon because they are easily confused with simple chronic infection. A neck node may be the first sign of disease.
Diagnosis is made by history, examination and palpation of the oropharyngeal structures. It is confirmed by biopsy. Other investigations to assess stage of the disease include chest X-ray, CT and MRI and Ultrasound of the neck.
Treatment is by surgery and radiotherapy.
Nasopharyngeal carcinoma is uncommon except in Cantonese patients, especially in Hong Kong. There are several risk factors that appear to act synergistically:
Positive family history
Epstein Barr virus infection
Diet rich in salt and Vit C deficiency
Lymphoma does also occur (Non-Hodgkin).
The symptoms are related to obstruction of the nasal airway and to extension of the tumour into adjacent structures. Thus the possibilities are:
Extension into the Cavernous sinus with diplopia due to cranial nerve palsy
Facial pain / numbness
Otitis media with effusion – unilateral
Surgery has a limited role and radiotherapy with chemotherapy are the mainstays of management.
Squamous carcinoma of the hypopharynx is commonest in the piriform sinus and over half of patients will have lymph node metastasis at presentation. The other two sub-sites of the hypopharynx, the post cricoid and posterior pharyngeal wall, also often present with a lymph node.
Symptoms include dysphagia, odynaphagia, referred otalgia, and laryngeal symptoms.
Prognosis is poor if there are laryngeal palsy and nodal metastasis present. Tumour size and distant metastasis also contribute to this.
About a quarter of patients are untreatable at presentation. Surgery with radiotherapy and chemotherapy.
By far the commonest histological type is squamous carcinoma but adenocarcinoma from salivary tissue, lymphomas in lymphoid tissue and mucosal melanomas are all seen.
Smoking and excessive alcohol consumption are the commonest causes but dental disease, poor nutrition and some chronic infections can predispose to it and work synergistically with smoke and alcohol to stimulate cancer genesis.
The human papilloma virus (subtype 16) is also relevant in cancer genesis. This is the same virus implicated in cervical cancer and is a common sexually transmitted pathogen.
Signs and symptoms
In the early stage small lesions may go unnoticed. As they enlarge a non-healing ulcer may be noticed. White or red patches may be visible and there may be bleeding from the lesion. Later in the disease induration, pain, bleeding, infection and halitosis, dysphagia, referred otalgia, trismus, and neck nodes appear.
This image shows a carcinoma on the lateral border of the tongue - the commonest site on the tongue.
The next image shows leukoplakia of the buccal mucosa.
Carcinoma affecting the right tonsil
Diagnosis is made by incisional biopsy. Staging of the disease requires radiological assessment including a chest X-ray and CT/MRI of the head and neck. An orthopantomogram is ordered if the disease affects or is near to the alveolar arches.
Surgical excision with adjunctive radiotherapy +/- chemotherapy is recommended. Depending on the site of the oral carcinoma mandibulectomy, maxillectomy, glossectomy, and radical neck dissection are possible options.
Dental extraction is performed prior to radiotherapy to decrease the risk of osteoradionecrosis of the mandible.
Image by Welleschik - Own work, CC BY-SA 3.0,
Photo taken by Michael Gaither, and he has agreed to release this picture with the following license., CC BY-SA 3.0,
Leukoplakia (literally white patch) is not a diagnosis. It is a description of a physical finding such as that seen in the image.
The underlying pathology may be candid infection, thickening of the oral mucosa, carcinoma in situ or invasive carcinoma. Predisposing factors are as for oral carcinoma: smoking, alcohol, and chronic trauma from sharp teeth.
The important thing about is that it needs a biopsy to make a diagnosis and in primary medical and dental care these patients are referred accordingly.